Stability of 5-Fluoro-2′-deoxycytidine and Tetrahydrouridine in Combination
نویسندگان
چکیده
منابع مشابه
Protective, tumor-selective dual pathway activation of 5-fluoro-2'-deoxycytidine provided by tetrahydrouridine in mice bearing mammary adenocarcinoma-755.
Treatment of C57BL X DBA/2 F (hereafter called BD2F) mice bearing ascitic mammary adenocarcinoma-755 (ADC-755) with [3H]-5-fluoro-2'-deoxycytidine ([3H]FdCyd) plus tetrahydrouridine (H4Urd) resulted in antimetabolite pool sizes indicative of a tumor-selective, dual pathway metabolism of FdCyd via both cytidine deaminase and deoxycytidine kinase. In contrast to the high levels of all RNA- and DN...
متن کاملTumor-selective metabolism of 5-fluoro-2'-deoxycytidine coadministered with tetrahydrouridine compared to 5-fluorouracil in mice bearing Lewis lung carcinoma.
The metabolic products formed and incorporated into the nucleic acids (RNA and DNA) of mice bearing Lewis lung carcinoma (LLC) following optimal doses of 5-fluorouracil (FUra), 5-fluoro-2'-deoxyuridine (FdUrd), and 5-fluoro-2'-deoxycytidine (FdCyd) coadministered with tetrahydrouridine (H4Urd), a potent inhibitor of cytidine deaminase, were examined. Treatment with FdCyd plus H4Urd resulted in ...
متن کاملGrowth inhibition of a human tumor cell strain by 5-fluorocytidine and 5-fluoro-2'-deoxycytidine: reversal studies.
The tumor-inhibitory and anti-leukemic activity of 5-fluorocytidine (FCR) t and 5-fluoro-2'-deoxycytidine (FCDR) has recently been reported (2, 12). Heidelberger et al. showed that 5-fluorocytosine was not active against a number of transplanted tumors in rats and mice (14, 15). In the experiments reported below the growth inhibition of H.Ep. #1 cells in culture by these 5-fluoro-substituted de...
متن کامل2′-Fluoro-3′,5′-dimethoxyacetanilide
Mol-ecules of the title compound, C(10)H(12)FNO(3), are nearly planar considering all non-H atoms with a mean deviation of 0.0288 Å. Mol-ecules are linked through inter-molecular N-H⋯O and N-H⋯F hydrogen bonds.
متن کاملstability and attraction domains of traffic equilibria in day-to-day dynamical system formulation
در این پژوهش مسئله واگذاری ترافیک را از دید سیستم های دینامیکی فرمول بندی می کنیم.فرض کرده ایم که همه فاکتورهای وابسته در طول زمان ثابت باشند و تعادل کاربر را از طریق فرایند منظم روزبه روز پیگیری کنیم.دینامیک ترافیک توسط یک نگاشت بازگشتی نشان داده می شود که تکامل سیستم در طول زمان را نشان می دهد.پایداری تعادل و دامنه جذب را توسط مطالعه ویژگی های توپولوژیکی تکامل سیستم تجزیه و تحلیل می کنیم.پاید...
ذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2010
ISSN: 1530-9932
DOI: 10.1208/s12249-010-9383-2